Katagiri T, Shimamoto T, Sashida G, Kato Y, Okada T, Ohyashiki K
Haematologica. 2001 Aug;86(8):E15.
We report here a case of adult T-cell leukemia (ATL) who presented acute renal failure and skin eruption. Renal and skin biopsies showed diffuse invasion of ATL cells. Furthermore, the surface phenotype of tumor cells taken from the bone marrow (BM) or peripheral blood (PB)(CD4-CD8-) differed from that of cells taken from the kidney or skin (CD4+CD8-). These findings suggested that CD4-CD8-ATL cells in the BM and PB had differentiated to CD4+CD8- cells in the kidney and skin.
我们在此报告一例成人T细胞白血病（ATL）患者，该患者出现急性肾衰竭和皮疹。肾脏和皮肤活检显示有ATL细胞的弥漫性浸润。此外，取自骨髓（BM）或外周血（PB）的肿瘤细胞表面表型（CD4-CD8-）与取自肾脏或皮肤的细胞（CD4+CD8-）不同。这些发现提示，BM和PB中的CD4-CD8-ATL细胞已分化为肾脏和皮肤中的CD4+CD8-细胞。
