Takasaki Yumi, Iwanaga Masako, Tsukasaki Kunihiro, Kusano Miyuki, Sugahara Kazuyuki, Yamada Yasuaki, Kamihira Shimeru, Ikeda Shuichi, Tomonaga Masao
Department of Molecular Medicine and Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Leuk Res. 2007 Jun;31(6):751-7. doi: 10.1016/j.leukres.2006.11.013. Epub 2006 Dec 22.
Multiple visceral involvements and various blood cell count abnormalities are frequently manifested in adult T-cell leukemia/lymphoma (ATLL) at diagnosis. We evaluated the effects of four visceral involvement (bone marrow (BM), skin, liver, spleen) and six blood cell count abnormalities (anemia, neutrophilia, thrombocytopenia, monocytosis, eosinophilia, basophilia) on the overall survival of 168 ATLL patients. In the aggressive type, BM involvement, skin involvement and monocytosis were significantly poor prognostic factors. Furthermore, concomitant involvement of BM and additional visceral organs worsened the prognosis. These data support that multiple organ involvements represent a poor prognostic factor for ATLL and provide clinical significance for BM examinations.
成人T细胞白血病/淋巴瘤（ATLL）在诊断时常常表现出多脏器受累及多种血细胞计数异常。我们评估了四种脏器受累情况（骨髓（BM）、皮肤、肝脏、脾脏）及六种血细胞计数异常（贫血、中性粒细胞增多、血小板减少、单核细胞增多、嗜酸性粒细胞增多、嗜碱性粒细胞增多）对168例ATLL患者总生存期的影响。在侵袭性类型中，骨髓受累、皮肤受累及单核细胞增多是显著的不良预后因素。此外，骨髓与其他脏器同时受累会使预后更差。这些数据支持多脏器受累是ATLL的不良预后因素，并为骨髓检查提供了临床意义。
