[卤泛群致心律失常及QT间期延长]
[Cardiac rhythm disturbances and prolonged QT interval with halofantrine].
作者信息
Lavallée I, Marc E, Moulin F, Treluyer J M, Imbert P, Gendrel D
机构信息
Hôpital Saint-Vincent-de-Paul, 74-82, avenue Denfert-Rochereau, 75674 Paris, France.
出版信息
Arch Pediatr. 2001 Aug;8(8):795-800. doi: 10.1016/s0929-693x(01)00537-1.
OBJECTIVE
To determine the importance of prolonged QT interval and electrocardiographic changes in children treated with halofantrin for an acute malaria attack.
RESULTS
Out of 25 children treated with halofantrin, nine had an increase of QTc interval < 440 ms and ten a QTc > 440 ms on control 24 h after the first dose. A 9-year-old girl, treated with halofantrin, had bradycardia and increase of QTc interval for six days, with a normal halofantrin blood level.
CONCLUSION
These data show that cardiac monitoring during halofantrin treatment is mandatory in children as in adults. Contraindications of halofantrin treatment must be respected, particularly a long congenital QT interval.
目的
确定使用卤泛群治疗急性疟疾发作的儿童中QT间期延长和心电图变化的重要性。
结果
在25例接受卤泛群治疗的儿童中，9例在首剂后24小时对照时QTc间期增加<440毫秒，10例QTc>440毫秒。一名接受卤泛群治疗的9岁女孩出现心动过缓且QTc间期延长6天，其卤泛群血药浓度正常。
结论
这些数据表明，儿童卤泛群治疗期间的心脏监测与成人一样是必需的。必须遵守卤泛群治疗的禁忌证，尤其是先天性QT间期延长。
Zotero 插件