Hôpital Robert Debré, Paris, France.
Pathog Glob Health. 2012 May;106(2):124-5. doi: 10.1179/2047773212Y.0000000007.
In order to assess cardiac tolerance of halofantrine in children, we studied, retrospectively, 15 non complicated falciparum malaria cases treated with halofantrine, and focused on the effect on ventricular repolarisation. Our data showed that halofantrine can produce a moderate QTc prolongation without any life-threatening arrhythmia. As long as contraindications of the drug are respected, this treatment should be considered as a therapeutical option in young children presenting with non complicated falciparum malaria.
为了评估卤泛群在儿童中的心脏耐受性，我们回顾性研究了 15 例非复杂性恶性疟原虫感染患儿应用卤泛群的病例，并重点观察了对心室复极的影响。研究数据显示，卤泛群可导致中度 QTc 延长，但无致命性心律失常。只要遵守药物禁忌证，对于患有非复杂性恶性疟原虫感染的幼儿，这种治疗方法可作为一种治疗选择。
