Otubanjo O A, Mosuro A A
Department of Zoology, Marine Biology and Fisheries, University of Lagos, Lagos, Nigeria.
Mutat Res. 2001 Oct 18;497(1-2):131-8. doi: 10.1016/s1383-5718(01)00250-9.
Using the murine sperm-head abnormality test, the mutagenicity of pyrantel pamoate, levamisole, albendazole, mebendazole and niridazole was evaluated. Pyrantel pamoate and niridazole induced increases in sperm-head abnormalities statistically significant over the negative controls at all the dose levels that were considered; the induction was dose-dependent indicating that both drugs might be mutagenic. Levamisole, albendazole, mebendazole and thiabendazole, all were unable to induce statistically significant increases in sperm-head abnormalities over the negative controls at all the dose levels tested; there was no correlation between dose level of administered drugs and incidence of abnormal sperms, indicating that the drugs might not be mutagenic.
