Freyschmidt-Paul P, Ziegler A, McElwee K J, Happle R, Kissling S, Sundberg J P, Hoffmann R
Department of Dermatology, Philipp University, Deutschhausstrasse 9, 35033 Marburg, Germany.
Eur J Dermatol. 2001 Sep-Oct;11(5):405-9.
Alopecia areata-like hair loss has been observed in C3H/HeJ mice and can be defined as a tissue-restricted T cell mediated disease of the hair follicle. Because FK506 has been described as suppressing T cell mediated autoimmune diseases, we addressed the question whether topical treatment of C3H/HeJ mice with FK506 has a beneficial effect on alopecia areata (AA). For this purpose six C3H/HeJ mice with AA were treated topically with 0.1% FK506 ointment, four mice received the vehicle only. Four of six FK506-treated mice showed complete hair regrowth, whereas 1/4 vehicle-treated mice regrew hair. Mice treated successfully with FK506 had reduced perifollicular infiltrates of CD4+ and CD8+ cells and a decreased expression of MHC class I and II and ICAM-1 on hair follicle epithelium, compared to control mice. We conclude that topical treatment with FK506 is able to induce hair regrowth in AA of C3H/HeJ mice, most likely by suppressing the T cell mediated immune response.
在C3H/HeJ小鼠中观察到斑秃样脱发，可将其定义为一种毛囊组织受限的T细胞介导疾病。由于FK506已被描述为可抑制T细胞介导的自身免疫性疾病，我们探讨了用FK506局部治疗C3H/HeJ小鼠是否对斑秃（AA）有有益作用。为此，对6只患有AA的C3H/HeJ小鼠局部涂抹0.1% FK506软膏，4只小鼠仅接受赋形剂。6只接受FK506治疗的小鼠中有4只毛发完全再生，而接受赋形剂治疗的小鼠中只有1/4毛发再生。与对照小鼠相比，成功接受FK506治疗的小鼠毛囊周围CD4+和CD8+细胞浸润减少，毛囊上皮细胞上MHC I类和II类以及ICAM-1的表达降低。我们得出结论，局部应用FK506能够诱导C3H/HeJ小鼠AA模型毛发再生，最可能是通过抑制T细胞介导的免疫反应实现的。
