淋巴细胞在斑秃发病及治疗中的作用。
The role of lymphocytes in the development and treatment of alopecia areata.
作者信息
Guo Hongwei, Cheng Yabin, Shapiro Jerry, McElwee Kevin
机构信息
a 1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.
b 2 Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
出版信息
Expert Rev Clin Immunol. 2015;11(12):1335-51. doi: 10.1586/1744666X.2015.1085306. Epub 2015 Sep 7.
Abstract
Alopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri- and intra-follicular regions, and hair follicle disruption. Both CD4(+) and CD8(+) lymphocytes are abundant in AA lesions; however, CD8(+) cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8(+) cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the self-antigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8(+) cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.
摘要
斑秃（AA）的发生与先天性和适应性免疫细胞的激活、向毛囊周围和毛囊内区域的迁移以及毛囊破坏有关。CD4(+)和CD8(+)淋巴细胞在AA皮损中均大量存在；然而，CD8(+)细胞毒性T淋巴细胞更有可能进入毛囊内部，由此推测它们在AA的发生中起着重要作用。几种啮齿动物模型再现了人类自身免疫性疾病的重要特征，并表明CD8(+)细胞毒性T淋巴细胞是AA诱导和持续存在的根本要素。然而，引发事件、涉及的自身抗原以及分子信号通路，都需要进一步探索。研究CD8(+)细胞毒性T淋巴细胞及其在AA发生中的命运决定，可能会揭示新的和改进的治疗方法。
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