Ohshima A, Takigawa M, Tokura Y
Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan.
Eur J Dermatol. 2001 Sep-Oct;11(5):410-5.
We have shown that T cell receptor BV2- and BV8-bearing CD8+ cells are decreased in the peripheral blood of psoriatic patients, while T cells possessing these BVs accumulate in psoriatic lesions. T cells homing to skin express cutaneous lymphocyte-associated antigen (CLA), and bacterial superantigens that trigger psoriasis promote this expression. Roxithromycin has immunomodulatory potency and its effectiveness for psoriasis has been proposed. Therefore, we monitored BV usage and alteration of superantigen-promoted CLA expression in circulating CD8+ cells of psoriatics before and after roxithromycin therapy. After roxithromycin treatment, circulating BV2- and BV8-bearing CD8+ cells were increased and CD8+ cells exhibited reduced expression of CLA when stimulated in vitro with bacterial superantigens. It is suggested that roxithromycin downregulates augmented expression of CLA by CD8+ cells, thereby suppressing their skin-homing and elevating the numbers of circulating BV2- and BV8-positive CD8+ cells. Such events may be included in part in the improvement of psoriasis with roxithromycin.
我们已经表明，携带T细胞受体BV2和BV8的CD8+细胞在银屑病患者外周血中减少，而拥有这些BV的T细胞在银屑病皮损中积聚。归巢至皮肤的T细胞表达皮肤淋巴细胞相关抗原（CLA），引发银屑病的细菌超抗原可促进这种表达。罗红霉素具有免疫调节作用，有人提出其对银屑病有效。因此，我们监测了银屑病患者在罗红霉素治疗前后循环CD8+细胞中BV的使用情况以及超抗原促进的CLA表达的变化。罗红霉素治疗后，循环中携带BV2和BV8的CD8+细胞增加，并且当用细菌超抗原体外刺激时，CD8+细胞的CLA表达降低。提示罗红霉素下调CD8+细胞CLA的过度表达，从而抑制其归巢至皮肤，并增加循环中BV2和BV8阳性CD8+细胞的数量。这些事件可能部分参与了罗红霉素对银屑病的改善作用。
