Dermatology Department, College of Medicine, Qassim University, PO Box 30109, Buraidah 51477, Saudi Arabia.
Mediators Inflamm. 2012;2012:159354. doi: 10.1155/2012/159354. Epub 2012 May 17.
Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.
大环内酯类抗生素红霉素的长期治疗被证明可以改变弥漫性泛细支气管炎的临床病程，这一发现始于 20 世纪 80 年代末。自那时以来，人们发现除了具有抗菌作用外，大环内酯类药物还具有许多抗炎特性。这些观察结果为许多研究提供了依据，这些研究旨在评估大环内酯类药物在其他炎症性疾病中的用途，包括皮肤和毛发疾病，如酒渣鼻、银屑病、玫瑰糠疹、斑秃、大疱性类天疱疮和苔藓样糠疹。本文总结了一系列临床研究和病例报告，这些研究和报告涉及大环内酯类抗生素在治疗某些皮肤病方面的潜在益处，这些皮肤病主要被归类为非传染性疾病，并证明它们具有作为疾病修饰剂的潜力。
