Ge Y, Grossman R I, Udupa J K, Babb J S, Nyúl L G, Kolson D L
Department of Radiology, University of Pennsylvania Medical Center, Founders Bldg, Ground Floor, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
Radiology. 2001 Sep;220(3):606-10. doi: 10.1148/radiol.2203001776.
To determine the fractional brain tissue volume changes in the gray matter and white matter of patients with relapsing-remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load.
Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent magnetic resonance imaging. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from the total segmented gray matter and white matter in each group and were analyzed.
The fractional volume of white matter versus that of gray matter was significantly lower (-6.4%) in patients with MS (P <.0001) than in control subjects. Neither gray matter nor white matter fractional volume measurements correlated with clinical disability in the patients with MS.
Loss of brain parenchymal volume in patients with relapsing-remitting MS is predominantly confined to white matter. Analysis of fractional brain tissue volumes provides additional information useful in characterizing MS and may have potential in evaluating treatment strategies.
确定复发缓解型多发性硬化症（MS）患者灰质和白质中脑组织体积分数的变化，并将这些测量结果与临床残疾程度和总病变负荷相关联。
30例复发缓解型MS患者和25名健康对照者接受了磁共振成像检查。从每组的总分割灰质和白质中获取脑组织体积分数（相对于总颅内体积的组织体积）并进行分析。
MS患者白质体积分数与灰质体积分数相比显著降低（-6.4%）（P <.0001），低于对照者。MS患者的灰质和白质体积分数测量值均与临床残疾程度无关。
复发缓解型MS患者脑实质体积的损失主要局限于白质。脑组织体积分数分析为MS的特征描述提供了额外有用信息，并且在评估治疗策略方面可能具有潜力。
