Ge Y, Grossman R I, Udupa J K, Wei L, Mannon L J, Polansky M, Kolson D L
Department of Radiology, Hospital of the University of Pennsylvania, Founders, Philadelphia 19104-4283, USA.
Radiology. 2000 Mar;214(3):665-70. doi: 10.1148/radiology.214.3.r00mr30665.
To determine annual rates of volumetric changes in the whole-brain parenchyma of patients with relapsing-remitting and secondary progressive multiple sclerosis (MS) and test the hypothesis that these changes correlate with clinical disability.
A computer-assisted segmentation technique with thin-section magnetic resonance (MR) imaging was used in 36 patients with MS (27 relapsing-remitting, nine secondary progressive) and in 20 control subjects to quantify brain and cerebrospinal fluid volumes. To determine the degree of brain atrophy, the percentage brain parenchyma volume (PBV) relative to that of intracranial contents was calculated.
At the beginning of the study, the PBV was smaller in the MS group than in the control group (P = .007); brain parenchyma volumes were similar. The median rate of brain volume loss was 17.3 mL per year in patients with relapsing-remitting MS and 23.6 mL per year in those with secondary progressive MS. There was a negative correlation between brain atrophy and Expanded Disability Status Scale (EDSS) score in patients with secondary progressive MS (r = -0.69, P = .004) and no correlation in patients with relapsing-remitting MS. T2 lesion volume did not correlate with brain atrophy in either group.
The correlation between brain atrophy and EDSS score was better in patients with secondary progressive MS than in those with relapsing-remitting MS.
确定复发缓解型和继发进展型多发性硬化症（MS）患者全脑实质的年容积变化率，并检验这些变化与临床残疾相关的假设。
采用计算机辅助分割技术和薄层磁共振（MR）成像，对36例MS患者（27例复发缓解型，9例继发进展型）和20例对照者的脑和脑脊液容积进行量化。为确定脑萎缩程度，计算相对于颅内内容物的脑实质体积百分比（PBV）。
研究开始时，MS组的PBV低于对照组（P = .007）；脑实质体积相似。复发缓解型MS患者的脑体积年损失中位数为17.3 mL，继发进展型MS患者为23.6 mL。继发进展型MS患者的脑萎缩与扩展残疾状态量表（EDSS）评分呈负相关（r = -0.69，P = .004），复发缓解型MS患者则无相关性。两组中T2病变体积与脑萎缩均无相关性。
继发进展型MS患者的脑萎缩与EDSS评分之间的相关性优于复发缓解型MS患者。
