Devillers I, Dive G, De Tollenaere C, Falmagne B, de Wergifosse B, Rees J F, Marchand-Brynaert J
Unité de Chimie organique et médicinale, Université catholique de Louvain, Bâtiment Lavoisier, place L. Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
Bioorg Med Chem Lett. 2001 Sep 3;11(17):2305-9. doi: 10.1016/s0960-894x(01)00445-0.
A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.
已经制备了一系列在C-2和C-2/C-6处被取代的咪唑并吡嗪酮3。这些化合物表现为超氧阴离子的猝灭剂。活性较高的化合物在结构上与海萤萤光素（一种海洋生物发光的天然底物）相关。基于哈特里-福克不稳定性的理论参数已被研究。
