Fujisawa M, Dobashi M, Yamasaki T, Kanzaki M, Okada H, Arakawa S, Kamidono S
Department of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hum Reprod. 2001 Sep;16(9):1945-9. doi: 10.1093/humrep/16.9.1945.
The study aim was to clarify the relationship of serum inhibin B concentrations to recovery of spermatogenic function after varicocelectomy, both as a predictor of improvement in the seminogram and as a means of monitoring hormonal function after surgery.
Fifty-two varicocele patients, including five with normal sperm concentrations, were studied. Changes in the seminogram, serum hormone concentrations and serum inhibin B were evaluated in the 47 oligozoospermic patients after surgery. Preoperative inhibin B concentrations correlated significantly with serum concentrations of FSH (r = 0.598, P < 0.0001) and testosterone (r = 0.380, P < 0.02). Inhibin B concentrations also correlated significantly with sperm concentration (r = 0.351, P < 0.02) and total testicular volume (r = 0.578, P < 0.0001). No significant correlation was seen between inhibin B and the Johnsen score. Preoperative concentrations of inhibin B were higher in patients who increased their sperm concentration after surgery (responders) than in those without improved concentrations (non-responders). No significant difference was observed between pre- and postoperative inhibin B concentrations in responders or non-responders. However, 15 of 25 (60%) patients with increased inhibin B showed improvement of the seminogram, while only five of 22 (23%) patients with no change or a decrease in inhibin B had any improvement (P < 0.05).
Preoperative serum inhibin B concentration could not reliably predict a response to varicocelectomy. However, a change in serum inhibin B concentration after varicocelectomy might be helpful to evaluate the improvement of testicular function after varicocelectomy.
本研究旨在阐明精索静脉曲张手术后血清抑制素B浓度与生精功能恢复之间的关系，既作为精液分析改善的预测指标，也作为术后监测激素功能的一种手段。
对52例精索静脉曲张患者进行了研究，其中包括5例精子浓度正常的患者。对47例少精子症患者术后的精液分析、血清激素浓度和血清抑制素B进行了评估。术前抑制素B浓度与血清FSH浓度（r = 0.598，P < 0.0001）和睾酮浓度（r = 0.380，P < 0.02）显著相关。抑制素B浓度还与精子浓度（r = 0.351，P < 0.02）和睾丸总体积（r = 0.578，P < 0.0001）显著相关。抑制素B与约翰森评分之间未发现显著相关性。术后精子浓度增加的患者（反应者）术前抑制素B浓度高于精子浓度未改善的患者（无反应者）。反应者或无反应者术前和术后抑制素B浓度之间未观察到显著差异。然而，抑制素B升高的25例患者中有15例（60%）精液分析有改善，而抑制素B无变化或降低的22例患者中只有5例（23%）有任何改善（P < 0.05）。
术前血清抑制素B浓度不能可靠地预测精索静脉曲张手术的反应。然而，精索静脉曲张手术后血清抑制素B浓度的变化可能有助于评估精索静脉曲张手术后睾丸功能的改善情况。
