Wettengel R, Hartmann W, Fabel H
Med Klin. 1975 Jun 13;70(24):1048-51.
In 9 patients with chronic bronchitis and cor puomonale and in one patient with vascularly pulmonary hypertension the efficiency of 0,04 mug and 0,16 mug Sch 1000 (isopropylatropin,), applicated with metered dose inhaler referring to blood gases and hemodynamics was examined. Inhalation of drug was not followed by any variations either referring to hemodynamic parameters (pulmonary pressure, systemic blood pressure, cardiac output, peripheral resistance) nor to the blood gases. After a dosage as high as eigth time as normal side effects were not found.
对9例慢性支气管炎合并肺心病患者及1例血管性肺动脉高压患者，使用定量吸入器吸入0.04微克和0.16微克的Sch 1000（异丙托溴铵），检测其对血气和血流动力学的影响。吸入药物后，血流动力学参数（肺动脉压、体循环血压、心输出量、外周阻力）及血气均未出现任何变化。即使剂量高达正常剂量的八倍，也未发现副作用。
