Rao R
Guy's King's and St Thomas' Medical School, Guy's Hospital, St Thomas' Street, London SE1 9RT, UK.
Eur Neurol. 2001;46(2):63-9. doi: 10.1159/000050765.
The role of carotid stenosis in vascular cognitive impairment was reviewed using Medline, EMBASE, PsychLit and PsychInfo databases using the words "carotid stenosis", "neuropsychological tests" and "endarterectomy". Limited evidence exists for frontal lobe dysfunction associated with carotid stenosis, but there is a lack of systematic and prospective studies carried out in consecutive patients, including appropriate neuropsychological and MRI assessment. Possible pathophysiological processes suggested for cognitive impairment associated with carotid stenosis are suggested; these include chronic ischaemia and lacunar infarction; such mechanisms and resultant pathologies may co-exist in the presence of large-artery atheroma.
利用Medline、EMBASE、PsychLit和PsychInfo数据库，通过检索“颈动脉狭窄”、“神经心理学测试”和“动脉内膜切除术”等词汇，对颈动脉狭窄在血管性认知障碍中的作用进行了综述。关于与颈动脉狭窄相关的额叶功能障碍的证据有限，而且缺乏对连续患者进行的系统前瞻性研究，包括适当的神经心理学和MRI评估。文中提出了与颈动脉狭窄相关的认知障碍可能的病理生理过程；这些过程包括慢性缺血和腔隙性梗死；在存在大动脉粥样硬化的情况下，这些机制和由此产生的病变可能同时存在。
