Mselle J
Ophthalmologica. 2001 Sep-Oct;215(5):357-60. doi: 10.1159/000050885.
Twelve out of 15 patients (9 males and 6 females) with laboratory-proven fungal keratitis were treated with topical clotrimazole, a synthetic imidazole derivative. Their ages ranged from 8 to 70 years. The posttreatment visual acuities were significantly better than the pretreatment visual acuities. No significant biomicroscopic signs of ocular surface toxicity were noted. The ocular condition in 3 patients (all infected with Fusarium solani) deteriorated to blindness despite the antifungal therapy.
The clotrimazole usually marketed as dermatological preparation can be used in a diluted form to treat human keratomycosis safely and successfully. A combination with a polyene derivative should be considered in the treatment of fungal corneal infection due to Fusarium spp.
15例经实验室确诊的真菌性角膜炎患者（9例男性，6例女性）接受了局部克霉唑治疗，克霉唑是一种合成咪唑衍生物。他们的年龄在8至70岁之间。治疗后的视力明显优于治疗前的视力。未观察到明显的眼表毒性生物显微镜体征。尽管进行了抗真菌治疗，但3例患者（均感染茄病镰刀菌）的眼部状况恶化至失明。
通常作为皮肤科制剂销售的克霉唑可以稀释后安全、成功地用于治疗人类角膜真菌病。对于镰刀菌属引起的真菌性角膜感染，治疗时应考虑与多烯衍生物联合使用。
