Hirose H, Terasaki H, Awaya S, Yasuma T
Department of Ophthalmology, Nagoya University, School of Medicine, Japan.
Am J Ophthalmol. 1997 Dec;124(6):836-8. doi: 10.1016/s0002-9394(14)71701-5.
To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment.
Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.
Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.
Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.
报告两例严重真菌性角膜溃疡患者，经局部应用两性霉素B眼膏成功治愈。
两名患者在角膜异物取出术后均出现角膜溃疡和前房积脓。分别从患者1和患者2中分离出烟曲霉和茄病镰刀菌。通过抗真菌药敏试验，两性霉素B显示出最低的最低抑菌浓度。
局部应用两性霉素B眼膏使真菌性角膜溃疡得到显著改善。
抗真菌药敏试验有助于抗真菌药物的选择。两性霉素B眼膏是治疗由抗真菌耐药真菌引起的角膜真菌病的有前景的治疗方法之一。
