Cole C N
Nat Genet. 2001 Sep;29(1):6-7. doi: 10.1038/ng0901-6.
Biogenesis of eukaryotic mRNA requires several post-transcriptional processing steps that must be completed accurately before it can be exported. Several processing factors are known to associate with RNA polymerase II during elongation, thereby positioning them to mediate efficient RNA processing. mRNAs are exported as complexes containing several RNA-binding proteins and other proteins. A recent study indicates that some of these packaging proteins also associate with RNA polymerase II during transcription. This suggests close coordination and mechanistic coupling of the events required to produce and export functional mRNAs.
真核生物信使核糖核酸（mRNA）的生物合成需要几个转录后加工步骤，这些步骤必须在其能够输出之前准确完成。已知有几种加工因子在延伸过程中与RNA聚合酶II结合，从而使其定位以介导高效的RNA加工。mRNA作为包含几种RNA结合蛋白和其他蛋白质的复合物输出。最近的一项研究表明，这些包装蛋白中的一些在转录过程中也与RNA聚合酶II结合。这表明产生和输出功能性mRNA所需的事件之间存在密切的协调和机制耦合。
