Hagiwara Masatoshi, Nojima Takayuki
Department of Functional Genomics, Medical Research Institute; Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
J Biochem. 2007 Jul;142(1):11-5. doi: 10.1093/jb/mvm123. Epub 2007 Jun 13.
Eukaryotic gene expression is controlled in multi steps. Pre-messenger RNAs (pre-mRNAs) transcribed by RNA polymerase II (RNAPII) are capped at 5' end, spliced to remove introns and polyadenylated at 3' end. These processes are followed by other post-transcriptional steps that include mRNA export, translation and mRNA degradation. Recent studies have shown that individual events occurring during eukaryotic gene expression are coupled together under more elaborate regulatory controls. In this review, the molecular and functional cross-talks between transcription and the post-transcriptional events are overviewed.
真核基因表达在多个步骤中受到调控。由RNA聚合酶II（RNAPII）转录的前体信使RNA（pre-mRNA）在5'端加帽，剪接以去除内含子，并在3'端进行多聚腺苷酸化。这些过程之后是其他转录后步骤，包括mRNA输出、翻译和mRNA降解。最近的研究表明，真核基因表达过程中发生的各个事件在更精细的调控下相互关联。在这篇综述中，将概述转录与转录后事件之间的分子和功能相互作用。
