苯二氮䓬类药物的可辨别效应。
Discriminable effects of benzodiazepines.
作者信息
Overton D A
出版信息
Psychopharmacol Commun. 1976;2(4):339-43.
PMID:11529
Abstract
In a shock-escape T-maze task, rats rapidly discriminated diazepam, flurazepam and chloridazepoxide from no drug. The discriminable effects of these benzodiazepines were not completely interchangeable with those of barbiturate anesthetics. The dose-response curve for diazepam asymptoted over the range 15 to 100 mg/kg, ip whereas dose-response curves for flurazepam and chloridazepoxide were more linear.
摘要
在一项电击回避T型迷宫任务中，大鼠能迅速区分地西泮、氟西泮和氯氮䓬与无药物状态。这些苯二氮䓬类药物的可辨别效应与巴比妥类麻醉剂的效应并非完全可互换。地西泮的剂量 - 反应曲线在腹腔注射15至100毫克/千克的范围内趋于平稳，而氟西泮和氯氮䓬的剂量 - 反应曲线则更呈线性。
Zotero 插件