Neet K E, Campenot R B
Department of Biochemistry and Molecular Biology, Finch UHS/Chicago Medical School, North Chicago, Illinois 60064, USA.
Cell Mol Life Sci. 2001 Jul;58(8):1021-35. doi: 10.1007/PL00000917.
This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75NTR and Trk, act as receptors for NGF in neurons generated the discovery of other neurotrophic factors/receptor families and has enhanced our understanding of the development, survival, regeneration, and degeneration of the nervous system. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discussed in detail and compared to information available on the GDNF and CNTF families. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generates the cellular signal and retrograde transport.
本综述探讨神经营养因子的受体相互作用，重点关注神经生长因子（NGF）家族、胶质细胞源性神经营养因子（GDNF）家族和睫状神经营养因子（CNTF）家族的神经营养蛋白。神经元中两种蛋白p75NTR和Trk作为NGF受体这一发现，促成了其他神经营养因子/受体家族的发现，并加深了我们对神经系统发育、存活、再生和退变的理解。文中详细讨论了神经营养蛋白的结合动力学、配体-受体复合物的结构以及逆行运输机制，并与GDNF和CNTF家族的现有信息进行了比较。每个神经营养因子家族，即NGF、GDNF和CNTF，都有一组对家族中个别成员具有特异性的受体，以及一个对成员无特异性的共同受体，在某些家族中，该共同受体可产生细胞信号并进行逆行运输。
