[日照与饮用矿泉水对中山地区激素和免疫状态的联合影响（实验研究）]

[Combined effect of insolation and drinking mineral waters on hormonal and immune status in medium-height mountains.(Experimental study)].

作者信息

Polushina N D, Vasin V A, Kozhevnikov S A, Demeshko N I

出版信息

Vopr Kurortol Fizioter Lech Fiz Kult. 2001 Jan-Feb(1):28-30.

Abstract

80 Wistar male rats were kept for 24 days in moderate altitude conditions of mountain resort Teberda. Before the experiment and after it their blood was examined with enzyme immunoassay for hydrocortisone, T3, T4, TSH, with radioimmunoassay for insulin; glucose levels, dynamics of peripheral blood count, immune status were also measured. It was found that UV radiation has a negative effect on hormonal and immune status of healthy rats in medium-high mountains (hydrocortisone levels fell by 50%, insulin rose 5-6-fold, CIC rose by 24.2%, eosinophils count rose 3-fold, T-cell immunity and lymphocyte phagocyting activity got suppressed, lymphocyte/neutrophil proportion reduced by 35%. Intake of mineral water corrected all the negative effects of insolation but hyperinsulinemia decreased insignificantly.

摘要

80只雄性Wistar大鼠在山区度假胜地捷别尔达的中等海拔条件下饲养24天。实验前后，通过酶免疫分析法检测它们血液中的氢化可的松、T3、T4、促甲状腺激素（TSH），通过放射免疫分析法检测胰岛素；还测量了血糖水平、外周血细胞计数动态、免疫状态。结果发现，紫外线辐射对中高山地区健康大鼠的激素和免疫状态有负面影响（氢化可的松水平下降50%，胰岛素升高5至6倍，循环免疫复合物（CIC）升高24.2%，嗜酸性粒细胞计数升高3倍，T细胞免疫和淋巴细胞吞噬活性受到抑制，淋巴细胞/中性粒细胞比例降低35%）。饮用矿泉水纠正了日照的所有负面影响，但高胰岛素血症仅略有下降。