Voskuil M, van Royen N, Hoefer I, Buschmann I, Schaper W, Piek J J
Academisch Medisch Centrum, afd. Cardiologie, Meibergdreef 9, 1105 AZ Amsterdam.
Ned Tijdschr Geneeskd. 2001 Apr 7;145(14):670-5.
In patients with obstructive artery disease, two different forms of compensatory vessel growth occur; angiogenesis and arteriogenesis. Angiogenesis is the formation of a capillary network, through the activation and proliferation of endothelial cells in ischaemic tissue. Arteriogenesis is the transformation of pre-existent collateral arterioles into functional collateral arteries. Circulating blood cells, especially monocytes, play an important role in the arteriogenesis process. Animal experiments have demonstrated that local treatment with monocyte chemoattractant protein-1 results in an elevated accumulation of monocytes/macrophages and an increased growth of collateral vessels. The stimulation of arteriogenesis will probably result in a greater increase in blood flow to the ischaemic tissue, than the stimulation of angiogenesis. This can be explained by the difference in diameter between the collateral vessels formed in arteriogenesis and the capillaries formed in angiogenesis. Research to the efficacy of growth factors that stimulate the arteriogenesis process is still at an experimental stage. The stimulation of arteriogenesis is studied in models of both peripheral and coronary obstructive disease.
在患有阻塞性动脉疾病的患者中，会出现两种不同形式的代偿性血管生长，即血管生成和动脉生成。血管生成是通过缺血组织中内皮细胞的激活和增殖形成毛细血管网络。动脉生成是将预先存在的侧支小动脉转化为功能性侧支动脉。循环血细胞，尤其是单核细胞，在动脉生成过程中起重要作用。动物实验表明，用单核细胞趋化蛋白-1进行局部治疗会导致单核细胞/巨噬细胞的积累增加以及侧支血管生长加快。与血管生成的刺激相比，动脉生成的刺激可能会使缺血组织的血流量增加得更多。这可以通过动脉生成中形成的侧支血管与血管生成中形成的毛细血管在直径上的差异来解释。对刺激动脉生成过程的生长因子疗效的研究仍处于实验阶段。在周围性和冠状动脉阻塞性疾病模型中都对动脉生成的刺激进行了研究。
