Rocca Aldo, Tafuri Domenico, Paccone Marianna, Giuliani Antonio, Zamboli Anna Ginevra Immacolata, Surfaro Giuseppe, Paccone Andrea, Compagna Rita, Amato Maurizo, Serra Raffaele, Amato Bruno
Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyVia Sergio Pansini, 80131Naples, Italy.
Department of Sport Sciences and Wellness, University of Naples "Parthenope", Naples, Italy.
Open Med (Wars). 2017 Oct 21;12:308-322. doi: 10.1515/med-2017-0045. eCollection 2017.
Multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.
多能干细胞，如间充质干/基质细胞以及源自不同来源（如血管壁）的干细胞，正受到深入研究，旨在迅速将其已发现的特性从实验室转化到临床应用中。对血管壁驻留干细胞的募集、分化、存活、增殖、生长因子产生以及转导的信号通路进行了分析。我们研究了血管驻留干细胞的生物学特性，并从多个因素（如基质金属蛋白酶（MMPs））以及这些细胞的生物学、转化和临床特征的调控方面探索了它们之间的关系。在本综述中，我们描述了针对成人血管壁驻留多能血管干细胞（VW-SCs）的转化和临床研究方法，并报告了它们在替代性临床方法中的作用，即作为血管疾病（如动脉瘤或外周动脉阻塞性疾病）的细胞疗法。
