Has R
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Istanbul, Turkey.
Clin Exp Obstet Gynecol. 2001;28(3):187-90.
To evaluate the etiology and outcome of non-immune hydrops fetalis diagnosed in the first trimester of pregnancy.
30 cases with fetal hydrops diagnosed between 10 and 14 weeks of pregnancy at the prenatal diagnosis unit of Istanbul Medical Faculty were reviewed. Sonographic findings, fetal chromosome profiles, and outcomes were analyzed.
NIHF was found to be associated with structural abnormalities in 25 (83.3%) cases, and chromosomal abnormalities in nine (47.3%) of the 19 analyzed cases. Nuchal translucency measurements were greater than 3 mm in 28 of the cases (93.3%), and cystic hygroma was the most common detected abnormality (n: 22; 73.3%). All pregnancies with nonimmune hydrops resulted in abortion, intrauterine fetal death, or termination of the pregnancy.
Fetal hydrops diagnosed in the first trimester of gestation is associated with a higher incidence of aneuploidy, and it has a high mortality, even in fetuses with normal chromosomes.
评估妊娠早期诊断出的非免疫性胎儿水肿的病因及结局。
回顾了伊斯坦布尔医学院产前诊断科在妊娠10至14周期间诊断出的30例胎儿水肿病例。分析了超声检查结果、胎儿染色体图谱及结局。
25例（83.3%）非免疫性胎儿水肿与结构异常有关，在19例分析病例中有9例（47.3%）与染色体异常有关。28例（93.3%）病例的颈部透明带测量值大于3毫米，最常见的检测到的异常是颈部水囊瘤（n = 22；73.3%）。所有非免疫性胎儿水肿的妊娠均导致流产、宫内胎儿死亡或终止妊娠。
妊娠早期诊断出的胎儿水肿与非整倍体的发生率较高有关，即使染色体正常的胎儿其死亡率也很高。
