Tan H Y, Ang Y G
Psychological Care Centre, Medicine Institute, HQ SAF Medical Corps, Singapore.
Aust N Z J Psychiatry. 2001 Aug;35(4):512-9. doi: 10.1046/j.1440-1614.2001.00912.x.
The objective of this study is to provide a retrospective description of prodromal symptoms of young military servicemen with first-episode psychosis, and a comparison with first-episode non-psychotic disorders.
Thirty consecutive servicemen presenting with first-episode psychosis were studied. Thirty-four randomly selected servicemen from 123 with non-psychotic disorders served as comparison. A combination of unstructured and semistructured interviews with the patient and other informants was used to describe the prodromal symptoms.
The most common prodromal psychotic symptoms were social withdrawal (83%); anxiety (77%); sleep disturbance (77%); disturbance in attention, concentration or memory (73%); deterioration in studies in school (70%); depressed mood (63%); odd behaviour (53%); and anger or irritability (53%). Common symptoms found in first-episode psychosis and non-psychotic patients included sleep disturbance, anxiety, depressed mood and anger or irritability. Common symptoms that were associated with the psychotic prodrome were social withdrawal (p < 0.001), deterioration in school results (p < 0.001) and disturbance in attention, concentration or memory (p < 0.001). The psychotic prodrome was also associated with apathy (p < 0.001), odd behaviour (p < 0.001), doing nothing (p = 0.004) and thought blocking (p = 0.04).
Cognitive disturbances and attenuated negative symptoms appear to be more specific to the psychotic prodrome in young patients with first-episode psychosis.
本研究旨在对首次发作精神病的年轻军人的前驱症状进行回顾性描述,并与首次发作的非精神病性障碍进行比较。
对连续30例首次发作精神病的军人进行研究。从123例非精神病性障碍患者中随机选取34例军人作为对照。采用对患者及其他知情者进行非结构化和半结构化访谈相结合的方式来描述前驱症状。
最常见的前驱精神病性症状为社交退缩(83%);焦虑(77%);睡眠障碍(77%);注意力、专注力或记忆力障碍(73%);学业成绩下降(70%);情绪低落(63%);行为怪异(53%);愤怒或易激惹(53%)。首次发作精神病患者和非精神病患者共有的常见症状包括睡眠障碍、焦虑、情绪低落以及愤怒或易激惹。与精神病前驱症状相关的常见症状为社交退缩(p < 0.001)、学业成绩下降(p < 0.001)以及注意力、专注力或记忆力障碍(p < 0.001)。精神病前驱症状还与冷漠(p < 0.001)、行为怪异(p < 0.001)、无所事事(p = 0.004)以及思维中断(p = 0.04)有关。
认知障碍和减弱的阴性症状似乎在首次发作精神病的年轻患者的精神病前驱症状中更为特异。