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热休克蛋白20在猪颈动脉中的定位。

Localization of heat shock protein 20 in swine carotid artery.

作者信息

Rembold C M, Zhang E

机构信息

Cardiovascular Division, Department of Internal Medicine, University of Virginia, Health System Charlottesville, Virginia 22908, USA.

出版信息

BMC Physiol. 2001;1:10. doi: 10.1186/1472-6793-1-10. Epub 2001 Aug 14.

DOI:10.1186/1472-6793-1-10
PMID:11532202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC48151/
Abstract

BACKGROUND

Cyclic nucleotides can relax vascular smooth muscle by mechanisms distal to myosin regulatory light chain (MRLC) phosphorylation. This mechanism, termed relaxation without MRLC dephosphorylation, may be regulated by ser16 phosphorylation of heat shock protein 20 (HSP20).

RESULTS

Confocal imaging of HSP20 in smooth muscle tissues revealed that HSP20 was present throughout the cytoplasm, although some focal regions of the cytoplasm were found to contain more HSP20 than the remaining cytoplasm. The distribution of HSP20 within the cytoplasm was not altered by histamine, forskolin, or nitroglycerin.

CONCLUSION

Cytoplasmic localization of HSP20 is consistent with a potential function of HSP20 as a regulator of smooth muscle contractile force.

摘要

背景

环核苷酸可通过肌球蛋白调节轻链（MRLC）磷酸化远端的机制使血管平滑肌松弛。这种机制被称为无MRLC去磷酸化的松弛，可能受热休克蛋白20（HSP20）的丝氨酸16磷酸化调节。

结果

平滑肌组织中HSP20的共聚焦成像显示，HSP20存在于整个细胞质中，尽管发现细胞质的一些局部区域比其余细胞质含有更多的HSP20。组胺、福斯可林或硝酸甘油不会改变HSP20在细胞质内的分布。

结论

HSP20的细胞质定位与其作为平滑肌收缩力调节剂的潜在功能一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/859dbc6096ce/1472-6793-1-10-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/956e2a774240/1472-6793-1-10-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/97d815bc9277/1472-6793-1-10-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/859dbc6096ce/1472-6793-1-10-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/956e2a774240/1472-6793-1-10-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/97d815bc9277/1472-6793-1-10-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aca3/48151/859dbc6096ce/1472-6793-1-10-3.jpg

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2
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