溴结构域基序与“支架作用”？
Bromodomain motifs and "scaffolding"?
作者信息
Denis G V
机构信息
Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA.
出版信息
Front Biosci. 2001 Sep 1;6:D1065-8. doi: 10.2741/A668.
Abstract
Bromodomain-containing multiprotein complexes share some of the properties of signal transduction scaffolds. Insights from MAP kinase signaling scaffolds, for example, may provide useful perspectives for future studies of bromodomain proteins. The regulatory processes of modification (phosphorylation, acetylation, ubiquitination), turnover, nuclear compartmentalization, feedback regulation and signaling pathway specificity are all likely to contribute to the mechanisms by which bromodomain-containing multiprotein complexes control transcription.
摘要
含溴结构域的多蛋白复合物具有一些信号转导支架的特性。例如，丝裂原活化蛋白激酶信号支架的相关见解可能为未来对溴结构域蛋白的研究提供有用的视角。修饰（磷酸化、乙酰化、泛素化）、周转、核区室化、反馈调节和信号通路特异性等调控过程都可能参与含溴结构域的多蛋白复合物控制转录的机制。
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