Leech S N, Kolar A J, Barrett P D, Sinclair S A, Leonard N
Department of Dermatology, Dryburn Hospital, North Road, Durham DH1 5TW, UK.
J Clin Pathol. 2001 Sep;54(9):727-9. doi: 10.1136/jcp.54.9.727.
To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs).
Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1.
Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1.
The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.
研究细胞角蛋白20（CK20）和甲状腺转录因子1（TTF-1）的免疫组化染色是否有助于鉴别默克尔细胞癌（MCC）与转移性小细胞癌（SCC）。
对11例MCC和10例肺SCC进行CK20和TTF-1染色。
11例MCC中有10例对CK20抗体染色阳性。TTF-1均为阴性。没有SCC对抗CK20染色阳性，所有SCC对抗TTF-1染色均呈强阳性。
联合使用抗CK20和抗TTF-1能够可靠地区分MCC和转移性SCC，从而避免对必须排除转移性SCC的MCC患者进行详细的临床调查。
