CHU Lille, Department of Dermatology, University of Lille, F-59000 Lille, France.
Department of Medicine, University of Lille, H.Warembourg, F-59000 Lille, France.
Curr Oncol. 2023 Jul 2;30(7):6353-6361. doi: 10.3390/curroncol30070468.
Merkel cell carcinoma (MCC) is a rare type of neuroendocrine tumor. Palpebral localization represents 2.5% of MCCs. Surgery is not always possible due to the localization or comorbidities of elderly patients. We hypothesized that radiotherapy (RT) alone could be a curative treatment in patients contraindicated for oncological surgery.
We performed a retrospective monocentric study of patients with localized eyelid MCC treated with curative intent using curative radiotherapy.
Overall, 11 patients with histologically confirmed eyelid MCC were treated with curative radiotherapy. The median age was 77 years old (range: 53-94). Curative RT was decided mainly due to difficult localization and significant co-morbidities. The median lesion dose was 57 Gy (range: 47-70). Most patients had adjuvant lymph nodes irradiation with a median dose of 50 Gy ( = 9; 82%). The median follow-up was 62 months (6-152 months). None of the seven deaths were MCC-related. None of our patients relapsed during follow-up. Side effects related to radiotherapy were mild (no grade ≥ 2) and rare ( = 3, 21%).
Our data suggest that curative radiotherapy is an effective and safe treatment for Merkel cell carcinoma of the eyelid and periocular region. Radiotherapy alone allows limiting the aesthetic and functional sequelae in elderly and comorbid patients who are contraindicated for oncological surgery.
默克尔细胞癌（MCC）是一种罕见的神经内分泌肿瘤。眼睑定位占 MCC 的 2.5%。由于老年患者的定位或合并症，手术并非总是可行。我们假设单独放疗（RT）对于不适合肿瘤手术的患者可能是一种治愈性治疗。
我们对接受根治性放疗治疗的局部眼睑 MCC 患者进行了回顾性单中心研究。
共有 11 名经组织学证实的眼睑 MCC 患者接受了根治性放疗。中位年龄为 77 岁（范围：53-94）。根治性 RT 主要由于定位困难和严重合并症而决定。中位病变剂量为 57 Gy（范围：47-70）。大多数患者接受了辅助淋巴结照射，中位剂量为 50 Gy（ = 9；82%）。中位随访时间为 62 个月（6-152 个月）。7 例死亡均与 MCC 无关。在随访期间，我们没有患者复发。放疗相关副作用轻微（无≥2 级）且罕见（ = 3，21%）。
我们的数据表明，根治性放疗是治疗眼睑和眼周区域默克尔细胞癌的有效且安全的方法。单独放疗可限制不适合肿瘤手术的老年和合并症患者的美容和功能后遗症。
