Fouda M A
Department of Medicine, King Khalid University Hospital, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia.
Saudi Med J. 2000 Jan;21(1):31-5.
The coexistence of primary hyper-parathyroidism and pregnancy is very rare worldwide. It carries serious complications to the mother and fetus, therefore, early diagnosis and management is of paramount importance.
Over a period of 16 years from 1982-1997, 24 patients with primary hyperparathyroidism were identified from the central diagnostic index data base of King Khalid University Hospital. Out of these, only 3 women with primary hyperparathyroidism complicating pregnancy were identified.
All 3 women were in the fourth decade. Two of them had coexisting vitamin D deficiency with initially normal serum calcium and were misdiagnosed as cases of osteomalacia while the third had very high serum calcium on first presentation. A single parathyroid adenoma was identified in all 3 patients with 2 undergoing surgical removal of the adenoma. The third patient unfortunately had an abortion. The babies of the first 2 patients were born healthy with no complications.
Primary hyperparathyridism, even though rare in pregnancy, carries risks to the mother and fetus and therefore early screening for asymptomatic hyper-parathyroidism in all women of childbearing age and in the early antenatal period of pregnant women is recommended.
原发性甲状旁腺功能亢进与妊娠并存的情况在全球范围内非常罕见。它会给母亲和胎儿带来严重并发症，因此，早期诊断和治疗至关重要。
在1982年至1997年的16年期间，从哈立德国王大学医院的中央诊断索引数据库中识别出24例原发性甲状旁腺功能亢进患者。其中，仅识别出3例原发性甲状旁腺功能亢进合并妊娠的女性。
所有3名女性均处于四十多岁。其中2人同时存在维生素D缺乏，血清钙最初正常，被误诊为骨软化症，而第3人首次就诊时血清钙非常高。所有3例患者均发现单个甲状旁腺腺瘤，其中2例接受了腺瘤手术切除。不幸的是，第3例患者流产。前2例患者的婴儿健康出生，无并发症。
原发性甲状旁腺功能亢进虽然在妊娠中罕见，但会给母亲和胎儿带来风险，因此建议对所有育龄妇女和孕妇的早期孕期进行无症状甲状旁腺功能亢进的早期筛查。
