Kristoffersson A, Dahlgren S, Lithner F, Järhult J
Surgery. 1985 Mar;97(3):326-30.
The history of a pregnant woman with primary hyperparathyroidism is presented. The patient underwent successful operation during the second trimester and the subsequent pregnancy and delivery were completely normal. Previously, 72 women with an established diagnosis of hyperparathyroidism in pregnancy are reported in the English literature. Twenty-three women underwent operation during pregnancy and 18 normal children were born. Fifty women with a total of 79 pregnancies during a hyperparathyroid state bore 35 normal children while 40 births had different kinds of complications. It is thus clearly documented that the risk of severe fetal complications is much higher if the hyperparathyroidism is left untreated than if the mother undergoes operation during the pregnancy. Therefore when the diagnosis is established the mother should undergo operation, if possible during the second trimester, which minimizes the complication rate significantly in both mother and child. Correction of the hypercalcemic state enables the development of adequate parathyroid gland function in the baby.
本文介绍了一位患有原发性甲状旁腺功能亢进症的孕妇的病史。该患者在孕中期接受了成功的手术，随后的妊娠和分娩完全正常。此前，英文文献报道了72例已确诊妊娠合并甲状旁腺功能亢进症的女性。23名女性在孕期接受了手术，产下18名正常婴儿。50名处于甲状旁腺功能亢进状态的女性共有79次妊娠，其中35名产下正常婴儿，40次分娩出现了不同类型的并发症。因此，有明确记录表明，如果甲状旁腺功能亢进症不治疗，严重胎儿并发症的风险比母亲在孕期接受手术要高得多。所以，一旦确诊，母亲应接受手术，若可能应在孕中期进行，这能显著降低母婴双方的并发症发生率。纠正高钙血症状态有助于婴儿甲状旁腺功能的正常发育。
