妊娠合并子痫前期和妊娠高血压综合征后10年高血压及其与肾功能的关系

Hypertension and its relation to renal function 10 years after pregnancy complicated by pre-eclampsia and pregnancy induced hypertension.

作者信息

Shammas A G, Maayah J F

机构信息

Department of Obstetrics & Gynecology, Royal Medical Services, PO Box 442, Madaba, Jordan.

出版信息

Saudi Med J. 2000 Feb;21(2):190-2.

PMID:11533780

Abstract

OBJECTIVE

To assess the development of hypertension and its relation to renal function 10 years after pregnancy complicated by pre-eclampsia and pregnancy induced hypertension.

METHODS

Women with pre-eclampsia (n=47), pregnancy induced hypertension (n=54) or normotensive (n=46) during 1988 were reviewed at King Hussein Medical Center, Amman, Jordan, for the development of hypertension and renal disorder. Their renal function was reviewed by measuring blood levels of urea, uric acid, creatinine, calcium and albumin. Urine was examined for microalbuminuria.

RESULTS

Women with pre-eclampsia and pregnancy induced hypertension had a higher risk of developing hypertension 10 years later compared to the control group, (23% for pre-eclampsia, and 39% for pregnancy induced hypertension vs. 3% for control). Albumin corrected calcium levels were significantly higher in patients with history of pre-eclampsia (2.41 mmol/l) and pregnancy induced hypertension (2.42 mmol/l) vs. control (2.33 mmol/l) as well as a significant difference in microalbuminuria levels (23% in pre-eclampsia, and 16% in pregnancy induced hypertension vs. 3% in control). Serum urea, creatinine and uric acid levels were not significantly affected (4.4 mmol/l in pre-eclampsia, 4.7 mmol/l in pregnancy induced hypertension and 4.6 mmol/l in control for urea, 76.0 mmol/l in pre-eclampsia, 74.0 mmol/l in pregnancy induced hypertension and 77.0 mmol/l in control for creatinine and 252.0 mmol/l in pre-eclampsia, 250.0 in pregnancy induced hypertension and 248 mmol/l in control for uric acid).

CONCLUSION

The risk of development of chronic hypertension 10 years after pregnancy complicated by pre-eclampsia and pregnancy induced hypertension is increased and this is closely related to residual renal disorder.

摘要

目的

评估子痫前期和妊娠高血压综合征合并妊娠10年后高血压的发生情况及其与肾功能的关系。

方法

1988年期间患有子痫前期（n = 47）、妊娠高血压综合征（n = 54）或血压正常（n = 46）的女性在约旦安曼的侯赛因国王医疗中心接受了高血压和肾脏疾病发展情况的复查。通过测量血液中的尿素、尿酸、肌酐、钙和白蛋白水平来评估她们的肾功能。检测尿液中的微量白蛋白尿。

结果

与对照组相比，子痫前期和妊娠高血压综合征患者在10年后发生高血压的风险更高（子痫前期为23%，妊娠高血压综合征为39%，而对照组为3%）。子痫前期病史患者（2.41 mmol/l）和妊娠高血压综合征病史患者（2.42 mmol/l）的白蛋白校正钙水平显著高于对照组（2.33 mmol/l），微量白蛋白尿水平也存在显著差异（子痫前期为23%，妊娠高血压综合征为16%，而对照组为3%）。血清尿素、肌酐和尿酸水平未受到显著影响（子痫前期尿素为4.4 mmol/l，妊娠高血压综合征为4.7 mmol/l，对照组为4.6 mmol/l；子痫前期肌酐为76.0 mmol/l，妊娠高血压综合征为74.0 mmol/l，对照组为77.0 mmol/l；子痫前期尿酸为252.0 mmol/l，妊娠高血压综合征为250.0 mmol/l，对照组为248 mmol/l）。