Egwuatu V E
Trop Geogr Med. 1986 Mar;38(1):11-5.
Single estimations of plasma urea, uric acid and creatinine were made in late pregnancy in 34 Nigerian primigravidae with mild/moderate or severe pregnancy-induced hypertension, and in 34 matched primigravidae with uncomplicated pregnancy. The differences in mean plasma concentrations of uric acid and creatinine between the pre-eclamptic patients and the normotensive controls were statistically significant, while that in mean urea levels was not. Patients with severe (proteinuric) pre-eclampsia showed significantly higher plasma urea and urate concentrations than women with mild/moderate (aproteinuric) disease, but the difference in mean plasma creatinine values between the two groups was not significant. In the pre-eclamptic group, changes in the plasma concentrations of the substances were more prominently correlated with the degree of proteinuria than the level of hypertension. Of the three substances examined, changes in the blood urate concentrations were the most pronounced. The slight fall in the mean blood urea level in patients with mild/moderate pre-eclampsia followed by an abrupt and significant rise as pre-eclampsia became severe might reflect variations in fluid distribution rather than raised urea production or impaired excretion. High blood uric acid and urea levels in women with proteinuric pre-eclampsia are associated with increased fetal risk and should be an indication for closer monitoring of the function of the feto-placental unit.
对34名患有轻度/中度或重度妊娠高血压综合征的尼日利亚初产妇以及34名匹配的无并发症初产妇在妊娠晚期进行了血浆尿素、尿酸和肌酐的单次测定。子痫前期患者与血压正常对照组之间尿酸和肌酐的平均血浆浓度差异具有统计学意义，而尿素平均水平的差异则无统计学意义。重度（蛋白尿性）子痫前期患者的血浆尿素和尿酸盐浓度显著高于轻度/中度（无蛋白尿性）疾病的女性，但两组间血浆肌酐平均值的差异不显著。在子痫前期组中，这些物质的血浆浓度变化与蛋白尿程度的相关性比与高血压水平的相关性更为显著。在所检测的三种物质中，血尿酸浓度的变化最为明显。轻度/中度子痫前期患者的平均血尿素水平略有下降，随着子痫前期病情加重，血尿素水平突然显著升高，这可能反映了液体分布的变化，而非尿素生成增加或排泄受损。蛋白尿性子痫前期女性的高血尿酸和尿素水平与胎儿风险增加相关，应作为密切监测胎儿-胎盘单位功能的指征。
