Garza-Chapa Raul, De Los Angeles Rojas-Alvarado Ma., Cerda-Flores Ricardo M.
Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social (IMSS), Administración de Correos #4, Monterrey, Nuevo León, México.
Am J Hum Biol. 2000 Nov 1;12(6):721-728. doi: 10.1002/1520-6300(200011/12)12:6<721::AID-AJHB1>3.0.CO;2-I.
It has been hypothesized that the greater prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in Mexicans may be related to their greater degree of Amerindian genetic admixture (AGA). The aim of this unmatched case-control study was to correlate the prevalence of NIDDM with AGA in 10 Mexican Mestizo populations non-randomly selected by surname. A sample of 1,699 unrelated persons, >44 years and residing in the state of Nuevo León, was selected on the basis of paraphyletic or polyphyletic surnames and interviewed in the Instituto Mexicano del Seguro Social (IMSS). All subjects received a medical examination, and diabetes was diagnosed on the basis of World Health Organization criteria. Three genetic marker systems were analyzed, and the percentage of AGA was calculated. Logistic regression analysis was performed with the prevalence as the dependent variable and sex and surname as the independent variables. The Spearman rank-order correlation analysis was calculated between the age-adjusted prevalence (45-75+ years) and AGA. The correlation revealed a pattern of increasing prevalence of NIDDM with increasing Amerindian ancestry by surname. Am. J. Hum. Biol. 12:721-728, 2000. Copyright 2000 Wiley-Liss, Inc.
据推测，墨西哥人非胰岛素依赖型糖尿病（NIDDM）患病率较高可能与其较高程度的美洲印第安人基因混合（AGA）有关。这项非匹配病例对照研究的目的是将NIDDM的患病率与10个通过姓氏非随机选择的墨西哥混血人群中的AGA进行关联。根据并系或多系姓氏，选取了1699名年龄大于44岁且居住在新莱昂州的无亲属关系的人作为样本，并在墨西哥社会保障局（IMSS）进行了访谈。所有受试者都接受了医学检查，并根据世界卫生组织标准诊断糖尿病。分析了三个遗传标记系统，并计算了AGA的百分比。以患病率为因变量，性别和姓氏为自变量进行逻辑回归分析。计算了年龄调整后患病率（45 - 75岁以上）与AGA之间的斯皮尔曼等级相关分析。该相关性揭示了按姓氏划分的NIDDM患病率随美洲印第安人血统增加而增加的模式。《美国人类生物学杂志》12:721 - 728，2000年。版权所有2000年威利 - 利斯公司。
