Bakalska M B, Angelova P A, Kancheva L S, Nikolov B A, Atanasova N N
Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences, Sophia.
Morfologiia. 2001;119(1):69-72.
Cell type of mammalian testis which is involved in the synthesis and secretion of testosterone and the maintenance of spermatogenesis are the fully differentiated interstitial Leydig cells (LC). Their ultrastructure possesses the typical characteristics of steroid-producing cells. It has been generally accepted that two waves of proliferation and differentiation can be discerned during the development of the Leydig cell population in the rodent and human testis. Treatment with ethane dimethane sulphonate (EDS) destroys selectively LC. A new LC population develops in the following weeks and this model has been used by us to study the proliferation and differentiation of new LC. Our results support the suggestion that the regeneration of a new LC population following EDS administration shows many similarities with the formation of the adult type LC in the prepubertal mammalian testis.
参与睾酮合成与分泌以及维持精子发生的哺乳动物睾丸细胞类型是完全分化的间质Leydig细胞（LC）。它们的超微结构具有类固醇生成细胞的典型特征。一般认为，在啮齿动物和人类睾丸中Leydig细胞群体的发育过程中，可以辨别出两波增殖和分化。用乙烷二甲磺酸盐（EDS）处理可选择性地破坏LC。在接下来的几周内会形成新的LC群体，我们已使用该模型来研究新LC的增殖和分化。我们的结果支持以下观点：EDS给药后新LC群体的再生与青春期前哺乳动物睾丸中成年型LC的形成有许多相似之处。
