Foroumadi A, Mirzaei M, Shafiee A
Research Center of Kerman University of Medical Sciences, Kerman, Iran.
Pharmazie. 2001 Aug;56(8):610-2.
The design, synthesis and antituberculosis activity of a series of 2-aryl-5-methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazole-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Six compounds exhibited a very good activity (MIC < 6.25 micrograms/ml, % Inhibition = 100).
描述了一系列2-芳基-5-甲硫基-1,3,4-噻二唑（5a-b）、α-（5-芳基）-1,3,4-噻二唑-2-基硫代乙酸乙酯（8a-b）及相关化合物的设计、合成与抗结核活性。所有化合物均与利福平相比，针对结核分枝杆菌H37Rv菌株进行了测试。六种化合物表现出非常好的活性（最低抑菌浓度<6.25微克/毫升，抑制率=100%）。
