一些含有D，L-蛋氨酸部分的新型1,3,4-噻二唑和1,2,4-三唑化合物的合成及其抗菌活性
Synthesis and antimicrobial activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds having a D,L-methionine moiety.
作者信息
Pintilie Otilia, Profire Lenuta, Sunel Valeriu, Popa Marcel, Pui Aurel
机构信息
Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, Al. I. Cuza University, Bd. Carol I, no. 11, Iasi, Romania.
出版信息
Molecules. 2007 Jan 29;12(1):103-13. doi: 10.3390/12010103.
Abstract
New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.
摘要
通过1,4 - 二取代硫代氨基脲4a - e分别在酸性和碱性介质中进行分子内环化反应，合成了含有D,L - 蛋氨酸部分的新型1,3,4 - 噻二唑5a - e和1,2,4 - 三唑化合物6a - c。使用金黄色葡萄球菌ATCC 25923、炭疽芽孢杆菌ATCC 8705、蜡状芽孢杆菌ATCC 10987、藤黄八叠球菌ATCC 9341和大肠杆菌ATCC 25922菌株研究了合成化合物的潜在抗菌作用。新合成的化合物对炭疽芽孢杆菌和蜡状芽孢杆菌表现出有前景的活性。
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