用差分脉冲伏安法测定药物中的奥沙拉秦钠。
Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry.
作者信息
Uslu B, Yilmaz S, Ozkan S A
机构信息
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
出版信息
Pharmazie. 2001 Aug;56(8):629-32.
The electrochemical oxidation of olsalazine sodium was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy carbon disc electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 x 10(-6) M and 2 x 10(-4) M. This relationship has been applied to the determination of olsalazine in commercial capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.
采用玻碳圆盘电极，在不同缓冲体系中，通过循环伏安法、线性扫描伏安法、差分脉冲伏安法和方波伏安法研究了奥沙拉秦钠的电化学氧化。在pH 7.0的磷酸盐缓冲液中，使用差分脉冲伏安法测定奥沙拉秦，获得了最佳结果。电活性物质呈现出扩散控制的伏安波，其差分脉冲峰值电流在2×10⁻⁶ M至2×10⁻⁴ M范围内与奥沙拉秦浓度呈线性关系。该关系已应用于市售胶囊剂型中奥沙拉秦的测定。回收率研究表明所开发的测定方法具有良好的准确性和精密度。还报道了一种紫外分光光度法用于比较。
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