Kim K H, Kim H J, Jeun E Y, Seo S H, Hong S P, Kang J S, Youm J R, Lee S C
College of Pharmacy, Kangwon National University, Chuncheon, South Korea.
Arch Pharm Res. 2001 Aug;24(4):281-5. doi: 10.1007/BF02975092.
Enantiomers of five racemic beta2-agonists were investigated by capillary electrophoresis employing a hydroxypropyl-beta-cyclodextrin (HP-beta-CD). The effects of the concentration of HP-beta-CD added to the background electrolyte and of the pH of the buffer on the effective mobility and resolution of the studied compounds were examined. Very good resolution was achieved for terbutaline and clenbuterol; salbutamol and bambuterol was able to be partially resolved. Enantioselectivity and resolution were influenced by the concentration of the HP-beta-CD, buffer composition and pH.
采用羟丙基-β-环糊精（HP-β-CD）通过毛细管电泳法研究了五种外消旋β2-激动剂的对映体。考察了添加到背景电解质中的HP-β-CD浓度以及缓冲液pH对所研究化合物有效迁移率和分离度的影响。特布他林和克仑特罗实现了很好的分离；沙丁胺醇和班布特罗能够部分分离。对映体选择性和分离度受HP-β-CD浓度、缓冲液组成和pH的影响。
