药物对映体的毛细管电泳分离。V. 羟丙基-α-环糊精作为手性溶剂化剂

Separation of enantiomers of drugs by capillary electrophoresis. V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent.

作者信息

Koppenhoefer B, Epperlein U, Schlunk R, Zhu X, Lin B

机构信息

Institute for Organic Chemistry, University of Tübingen, Germany.

出版信息

J Chromatogr A. 1998 Jan 9;793(1):153-64. doi: 10.1016/s0021-9673(97)00880-7.

DOI:10.1016/s0021-9673(97)00880-7

PMID:9468655

Abstract

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths Rm. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization.

摘要

在一项扩展的手性药物筛选计划中，以羟丙基-α-环糊精作为手性溶剂化剂（CSA）对86种外消旋药物进行了对映体拆分测试。在这种直接的方法中，86种药物中有34种能够被拆分。在相同条件下进行的实验次数使得能够将分离因子α(m)与相互作用强度Rm关联起来。正如对23种药物的一个子集所显示的那样，CSA的浓度是进一步优化的关键参数。