Neylan T C, Metzler T J, Schoenfeld F B, Weiss D S, Lenoci M, Best S R, Lipsey T L, Marmar C R
Department of Psychiatry, University of California, and Veterans Affairs Medical Center, San Francisco 94121, USA.
J Trauma Stress. 2001 Jul;14(3):461-7. doi: 10.1023/A:1011100420978.
This study assesses the efficacy of fluvoxamine treatment on different domains of subjective sleep quality in Vietnam combat veterans with chronic posttraumatic stress disorder (PTSD). Medically healthy male Vietnam theater combat veterans (N = 21) completed a 10-week open label trial. Fluvoxamine treatment led to improvements in PTSD symptoms and all domains of subjective sleep quality. The largest effect was for dreams linked to the traumatic experience in combat. In contrast, generic unpleasant dreams showed only a modest response to treatment. Sleep maintenance insomnia and the item "troubled sleep" showed a large treatment response, whereas sleep onset insomnia improved less substantially. These therapeutic benefits contrast with published reports that have found activating effects of Selective Serotonin Reuptake Inhibitors on the sleep electroencephalogram.
本研究评估了氟伏沙明治疗对患有慢性创伤后应激障碍（PTSD）的越南退伍军人主观睡眠质量不同领域的疗效。身体健康的男性越南战区退伍军人（N = 21）完成了一项为期10周的开放标签试验。氟伏沙明治疗使PTSD症状和主观睡眠质量的所有领域均得到改善。最大的效果体现在与战斗创伤经历相关的梦境方面。相比之下，一般的不愉快梦境对治疗仅表现出适度反应。睡眠维持性失眠和“睡眠困扰”项目显示出较大的治疗反应，而入睡性失眠改善程度较小。这些治疗益处与已发表的报告形成对比，那些报告发现选择性5-羟色胺再摄取抑制剂对睡眠脑电图有激活作用。
