奈法唑酮对创伤后应激障碍患者主观和客观睡眠质量的影响。
The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder.
作者信息
Neylan Thomas C, Lenoci Maryanne, Maglione Melissa L, Rosenlicht Nicholas Z, Leykin Yan, Metzler Thomas J, Schoenfeld Frank B, Marmar Charles R
机构信息
Department of Psychiatry, University of California, and the Psychiatry Service, San Francisco Veterans Affairs Medical Center, 94121, USA.
出版信息
J Clin Psychiatry. 2003 Apr;64(4):445-50. doi: 10.4088/jcp.v64n0415.
BACKGROUND
This study assesses the efficacy of nefazodone treatment (target dose of 400-600 mg/day) on objective and subjective sleep quality in Vietnam combat veterans with chronic DSM-IV posttraumatic stress disorder (PTSD).
METHOD
Medically healthy male Vietnam theater combat veterans with DSM-IV PTSD (N = 10) completed a 12-week open-label trial. Two nights of ambulatory polysomnography were obtained at baseline and at the end of the trial. PTSD and depressive symptoms and subjective sleep quality were assessed at baseline and after 12 weeks. Data were collected in 1999 and 2000.
RESULTS
Nefazodone treatment led to a significant decrease in PTSD and depressive symptoms (p <.05), an improvement in global subjective sleep quality, and a reduction in nightmares. Nefazodone also resulted in a substantial improvement in objective measures of sleep quality, particularly increased total sleep time, sleep maintenance, and delta sleep as measured by period amplitude analysis.
CONCLUSION
Nefazodone therapy results in an improvement of both subjective and objective sleep quality in subjects with combat-related PTSD.
背景
本研究评估了奈法唑酮治疗（目标剂量为400 - 600毫克/天）对患有慢性DSM - IV创伤后应激障碍（PTSD）的越南退伍军人客观和主观睡眠质量的疗效。
方法
患有DSM - IV创伤后应激障碍的身体健康的男性越南战区退伍军人（N = 10）完成了一项为期12周的开放标签试验。在基线和试验结束时进行了两晚的动态多导睡眠图检查。在基线和12周后评估创伤后应激障碍和抑郁症状以及主观睡眠质量。数据收集于1999年和2000年。
结果
奈法唑酮治疗导致创伤后应激障碍和抑郁症状显著减轻（p <.05），整体主观睡眠质量改善，噩梦减少。奈法唑酮还使睡眠质量的客观指标有显著改善，特别是通过周期振幅分析测量的总睡眠时间增加、睡眠维持改善和慢波睡眠增加。
结论
奈法唑酮治疗可改善与战斗相关的创伤后应激障碍患者的主观和客观睡眠质量。
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