Mani S
Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Horm Behav. 2001 Sep;40(2):183-90. doi: 10.1006/hbeh.2001.1687.
Ovarian steroid hormones, estradiol and progesterone, regulate cellular functions in the central nervous system, resulting in the alterations in physiology and reproductive behavior. One means by which steroid hormones exert their neural effects on reproductive behavior is via their intracellular receptors functioning as ligand-dependent transcription factors. Studies from our laboratory in the past few years have shown that in addition to their cognate ligands, neurotransmitters like dopamine can activate intracellular steroid receptors in a ligand-independent manner. Using biochemical and molecular approaches we have demonstrated that the effects of neurotransmitter dopamine, on reproductive behavior in female rats and mice, occur by means of cross talk between membrane receptors for dopamine and intracellular progestin receptors (PRs). In this article, our studies on the integration of intracellular signaling pathways leading to the activation of PRs and its impact on modulation of reproductive behavior are summarized.
卵巢甾体激素，雌二醇和孕酮，调节中枢神经系统中的细胞功能，从而导致生理和生殖行为的改变。甾体激素对生殖行为发挥神经作用的一种方式是通过其作为配体依赖性转录因子的细胞内受体起作用。我们实验室过去几年的研究表明，除了其同源配体之外，像多巴胺这样的神经递质可以以配体非依赖性方式激活细胞内甾体受体。我们利用生化和分子方法证明，神经递质多巴胺对雌性大鼠和小鼠生殖行为的影响是通过多巴胺膜受体与细胞内孕激素受体（PRs）之间的相互作用实现的。在本文中，我们总结了关于导致PRs激活的细胞内信号通路整合及其对生殖行为调节影响的研究。
