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孕激素受体在雌性生殖行为中的激活：与神经递质的相互作用。

Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmitters.

机构信息

Dept. of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3411, USA.

出版信息

Front Neuroendocrinol. 2010 Apr;31(2):157-71. doi: 10.1016/j.yfrne.2010.01.002. Epub 2010 Jan 29.

DOI:10.1016/j.yfrne.2010.01.002
PMID:20116396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2849835/
Abstract

The steroid hormone, progesterone (P), modulates neuroendocrine functions in the central nervous system resulting in alterations in physiology and reproductive behavior in female mammals. A wide body of evidence indicates that these neural effects of P are predominantly mediated via their intracellular progestin receptors (PRs) functioning as "ligand-dependent" transcription factors in the steroid-sensitive neurons regulating genes and genomic networks. In addition to P, intracellular PRs can be activated by neurotransmitters, growth factors and cyclic nucleotides in a ligand-independent manner via crosstalk and convergence of pathways. Furthermore, recent studies indicate that rapid signaling events associated with membrane PRs and/or extra-nuclear, cytoplasmic PRs converge with classical PR activated pathways in neuroendocrine regulation of female reproductive behavior. The molecular mechanisms, by which multiple signaling pathways converge on PRs to modulate PR-dependent female reproductive behavior, are discussed in this review.

摘要

甾体激素孕酮（P）调节中枢神经系统的神经内分泌功能，导致雌性哺乳动物的生理和生殖行为发生改变。大量证据表明，P 的这些神经作用主要通过其细胞内孕激素受体（PRs）介导，作为甾体敏感神经元中的“配体依赖”转录因子，调节基因和基因组网络。除了 P，细胞内 PR 还可以通过信号转导的串扰和汇聚，以非配体依赖的方式被神经递质、生长因子和环核苷酸激活。此外，最近的研究表明，与膜 PR 和/或核外细胞质 PR 相关的快速信号事件与经典 PR 激活途径在雌性生殖行为的神经内分泌调节中汇聚。本文综述了多种信号通路如何汇聚到 PR 上来调节 PR 依赖性雌性生殖行为的分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/d4d7f28e8124/nihms175323f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/c9e268cdb059/nihms175323f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/4e4383c2e8f5/nihms175323f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/876db60bba16/nihms175323f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/934cffa868f2/nihms175323f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/d4d7f28e8124/nihms175323f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/c9e268cdb059/nihms175323f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/4e4383c2e8f5/nihms175323f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/876db60bba16/nihms175323f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/934cffa868f2/nihms175323f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dfb/2849835/d4d7f28e8124/nihms175323f5.jpg

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Role of progesterone receptor isoforms in female sexual behavior induced by progestins in rats.
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Neuroendocrinology. 2018;106(2):101-115. doi: 10.1159/000471878. Epub 2017 Apr 7.
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