Iguchi T, Watanabe H, Katsu Y
Center for Integrative Bioscience, Okazaki National Research Institutes, 38 Nishigonaka, Myodaiji, Okazaki 444-8585, Japan.
Horm Behav. 2001 Sep;40(2):248-51. doi: 10.1006/hbeh.2001.1675.
Laboratory experiments have demonstrated that exposure of rodents to sex hormones during prenatal or early postnatal life can cause permanent and irreversible alterations of the endocrine and reproductive organs, such as ovary, fallopian tube, uterus, cervix, vagina, and mammary gland in females; and testis, epididymis, prostate, and seminal vesicle in males; as well as non reproductive organs including bones and muscle and immune and nervous systems in both sexes. Early development of Xenopus laevis into the tadpole and Fundulus heteroclitus goes through a rapid cell division, gastrulation, neurulation, and organogenesis within 1 week after fertilization. The developing embryo is very fragile and sensitive to estrogenic agents. Thus, these animals can be used as a suitable model for examining the effect of endocrine disruptors (hormonally active agents) on the development of aquatic living beings, which are most likely to be exposed to the compounds.
实验室实验表明，啮齿动物在产前或产后早期接触性激素会导致内分泌和生殖器官发生永久性和不可逆的改变，如雌性的卵巢、输卵管、子宫、子宫颈、阴道和乳腺；雄性的睾丸、附睾、前列腺和精囊；以及两性的非生殖器官，包括骨骼、肌肉、免疫系统和神经系统。非洲爪蟾早期发育成蝌蚪，而美洲底鳉在受精后1周内经历快速细胞分裂、原肠胚形成、神经胚形成和器官发生。发育中的胚胎非常脆弱，对雌激素剂敏感。因此，这些动物可作为合适的模型，用于研究内分泌干扰物（激素活性物质）对水生生物发育的影响，因为水生生物很可能接触到这些化合物。
