Mukherjee B, Basu M, Chatterjee M
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Eur J Cancer Prev. 2001 Aug;10(4):347-55. doi: 10.1097/00008469-200108000-00008.
An association between low selenium intake and the incidence or prevalence of cancers is well known. Selenium in the form of selenomethionine supplemented in drinking water has been found to be highly effective in reducing tumour incidence and preneoplastic foci during the development of hepatocarcinogenesis in rats in our previous studies. Here, an attempt has been made to investigate whether the dose and form of selenium found to be effective during hepatocarcinogenesis is equally effective in N-methylnitronitrosoguanidine-induced colorectal carcinogenesis in terms of antioxidant defence enzyme systems, DNA chain breaks and incidences of aberrant crypt foci. Treatment with selenomethionine either on initiation or on selection/promotion, or during the entire experiment showed that selenomethionine was most effective in regulating the cellular antioxidant defence systems, DNA chain break control and reducing aberrant crypt foci in the colorectal tissues of rats. Our results also confirm that selenium is particularly effective in limiting the action of the carcinogen during the initiation phase of this colorectal carcinogenesis, just as we found with hepatocarcinogenesis in our previous studies.
低硒摄入量与癌症的发病率或患病率之间的关联是众所周知的。在我们之前的研究中，已发现饮用水中添加的硒代蛋氨酸形式的硒在降低大鼠肝癌发生发展过程中的肿瘤发病率和癌前病灶方面非常有效。在此，我们试图研究在肝癌发生过程中被发现有效的硒的剂量和形式，在N-甲基亚硝基胍诱导的结直肠癌发生中，就抗氧化防御酶系统、DNA链断裂和异常隐窝病灶的发生率而言是否同样有效。在起始阶段、选择/促进阶段或整个实验过程中用硒代蛋氨酸进行处理表明，硒代蛋氨酸在调节细胞抗氧化防御系统、控制DNA链断裂以及减少大鼠结直肠组织中的异常隐窝病灶方面最为有效。我们的结果还证实，正如我们在之前的肝癌发生研究中所发现的那样，硒在这种结直肠癌发生的起始阶段特别有效地限制了致癌物的作用。
