Waksmański B, Dudkiewicz J, Kowalski T
Department and Clinic of Gynaecology in Zabrze, Silesian Medical University, Katowice, Poland.
Med Sci Monit. 2001 Sep-Oct;7(5):919-23.
The aim of this research was to observe changes in IGF-I and steroid hormones in postmenopausal women with benign and malignant ovarian tumors.
The concentrations of insulin-like growth factor I (IGF-I), 17-b-estradiol and progesterone were examined by radioimmunological assay in three groups of postmenopausal women: patients with malignant ovarian tumors, patients with benign ovarian tumors, and healthy women. In all three groups the age and body mass index (BMI) were comparable.
The concentrations of IGF-I in the serum of the patients with malignant cancer were significantly lower. The concentrations of estradiol were significantly higher in the patients with both benign and malignant ovarian tumors as compared to the controls.
Decreased IGF-I concentration in the serum of postmenopausal women with ovarian tumors may suggest that the tumor is malignant.
本研究的目的是观察患有良性和恶性卵巢肿瘤的绝经后女性中胰岛素样生长因子I（IGF-I）和甾体激素的变化。
采用放射免疫分析法检测三组绝经后女性体内胰岛素样生长因子I（IGF-I）、17-β-雌二醇和孕酮的浓度：恶性卵巢肿瘤患者、良性卵巢肿瘤患者和健康女性。三组的年龄和体重指数（BMI）具有可比性。
恶性肿瘤患者血清中IGF-I的浓度显著降低。与对照组相比，良性和恶性卵巢肿瘤患者体内雌二醇的浓度均显著升高。
患有卵巢肿瘤的绝经后女性血清中IGF-I浓度降低可能提示肿瘤为恶性。
