Hussell T, Pennycook A, Openshaw P J
Department of Respiratory Medicine, National Heart and Lung Institute at St Mary's Hospital, Imperial College of Science, Technology and Medicine, London, GB.
Eur J Immunol. 2001 Sep;31(9):2566-73. doi: 10.1002/1521-4141(200109)31:9<2566::aid-immu2566>3.0.co;2-l.
TNF antagonists are effective treatments for rheumatoid arthritis and Crohn's disease, and have been tried with variable success in other diseases caused by immune damage. To test the hypothesis that viral lung diseases caused by respiratory syncytial virus or influenza virus are partly due to overproduction of TNF, we used anti-TNF antibody to treat mice with lung disease caused by these viruses. TNF depletion reduced pulmonary recruitment of inflammatory cells, cytokine production by T cells and the severity of illness without preventing virus clearance. These broad beneficial effects suggest that TNF antagonists might be tested as treatments of human viral lung diseases.
肿瘤坏死因子拮抗剂是治疗类风湿性关节炎和克罗恩病的有效药物，并且在其他由免疫损伤引起的疾病中也进行了尝试，取得了不同程度的成功。为了验证呼吸道合胞病毒或流感病毒引起的病毒性肺部疾病部分是由于肿瘤坏死因子过度产生这一假说，我们使用抗肿瘤坏死因子抗体来治疗由这些病毒引起肺部疾病的小鼠。肿瘤坏死因子的减少降低了炎症细胞向肺部的募集、T细胞产生细胞因子的能力以及疾病的严重程度，同时并未阻止病毒的清除。这些广泛的有益作用表明，肿瘤坏死因子拮抗剂可能作为人类病毒性肺部疾病的治疗方法进行试验。
