Forsberg E C, Bresnick E H
Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 13090 University Avenue, Madison, WI 53706, USA.
Bioessays. 2001 Sep;23(9):820-30. doi: 10.1002/bies.1117.
Histone acetylation is an important regulatory mechanism that controls transcription and diverse nuclear processes. While great progress has been made in understanding how localized acetylation and deacetylation control promoter activity, virtually nothing is known about the consequences of acetylation throughout entire chromosomal regions. An increasing number of genes have been found to reside in large chromatin domains that are controlled by regulatory elements many kilobases away. Recent studies have shown that broad histone acetylation patterns are hallmarks of chromatin domains. The purpose of this review is to discuss how such patterns are established and their implications for regulating gene expression.
组蛋白乙酰化是一种重要的调控机制，可控制转录及多种核过程。虽然在理解局部乙酰化和去乙酰化如何控制启动子活性方面已取得巨大进展，但对于整个染色体区域乙酰化的后果却几乎一无所知。越来越多的基因被发现位于大型染色质结构域中，这些结构域由数千碱基以外的调控元件控制。最近的研究表明，广泛的组蛋白乙酰化模式是染色质结构域的标志。本综述的目的是讨论这些模式是如何建立的以及它们对基因表达调控的意义。
